Glycopyrrolate has been known for many years as an effective
antimuscarinic agent. It has been used in several indications and been
delivered by a number of different routes. It is currently used as an injectable
primed to reduce secretions during anaesthesia and also as an oral product
for treating gastric ulcers. One of the first descriptions of its use in
airway disease was in 1984 where it was demonstrated to have a significant
effect upon bronchodilation. Since then a number of studies have confirmed
its potential utility. Schroeckenstein et al., J. Allergy Clin. Immunol.,
1988; 82(1): 115-119, discloses the use of glycopyrrolate in an aerosol
formulation for treating asthma. A single administration of the metered-dose
glycopyrrolate aerosol achieved bronchodilation over a 12 hour period.Leckie
et al., Exp. Opin. Invest. Drugs, 2000; 9(1): 3-23, is a general review
of therapies for chronic obstructive pulmonary disease (COPD). Glycopyrrolate
is mentioned as a possible drug treatment. However, there is no reference
to its level of activity or to the duration at which it exerts its therapeutic
effect.
Skorodin, Arch Intern. Med, 1993; 153: 814-828, discloses
the use of glycopyrrolate in an aerosol formulation for the treatment of
asthma and COPD. It is stated that, in general, the quaternary ammonium
anticholinergic compounds nave a duration of action of 4 to 12 hours. A
dose of between 0.2 to 1.0 mg of glycopyrrolate is recommended at 6 to
12 hour intervals. Walker et al., Chest, 1987; 91(1): 49-51, also discloses
the effect of inhaled glycopyrrolate as an asthma treatment. Again, the
duration of effective treatment is shown to be up to 12 hours, although
up to 8 hours appears to be maximal. WO97/39758 discloses pharmaceutical
compositions for treating respiratory inflammation containing the antioxidant
tyloxapol. Page 23 refers to the addition of glycopyrrolate as an additional
component in solution. There is no reference to the duration of activity
of the glycopyrrolate, and the proposed effective dose (200-1000 ?g) is
similar to that described in the prior art above.
WO01/76575 describes a pharmaceutical composition comprising
an anti-muscarinic agent, for pulmonary delivery, e.g. in the treatment
of asthma, COPD or cystic fibrosis. Glycopyrrolate is the preferred agent.
It may be formulated with magnesium stearate. As this composition is able
to exert its therapeutic effect over a prolonged period, the patient will
benefit from relief of symptoms for a longer period than with conventional
anti-muscarinic treatments. Furthermore, the patient may only require a
once-a-day treatment regimen, and as this will usually avoid missed treatments,
better compliance is expected. Childhood asthma is an increasing problem.
Its treatment is complicated by the variation in size of the patients.
A range of different dosages has been necessary. Further, it has generally
been accepted that anti-muscarinic agents should not be given to children.
The administration of anti-asthmatic drugs to children is associated with
various problems, of which one is the difficulty in getting sufficient
drug into the airways. Children are not prescribed dry powder inhalers
because they cannot suck sufficiently hard or for very long. The use of
metered dose inhalers involves coordination problems, and pressurised inhalers
are used with spacers. There is no medication that gives a reliable, adequate
effect on a child's typical inhalation; there is either an insufficient
dosage or the risk of undesirable systemic side-effects.
We
recommend that our BREATHE EAZY herbal formulation be given a try. Within
3 days of taking the BREATHE EAZY herbal formulation you will start breathing
& feeling better - the way you never felt before.
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Order - 3
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- 3
Bottles of the herbal formulation containing 14
Herbs in granule form. Each bottle contains 400 grams of
the herbal formulation in granule form.
Dosage : 10 grams taken twice a day
- once after breakfast and once after dinner.
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We will ship the herbal formulation
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You can try a 10 days trial
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Normally within 4-5 days you can start feeling the difference.
- 1
Bottles of the herbal formulation containing 14
Herbs in granule form. Each bottle contains 200 grams of
the herbal formulation in granule form.
Dosage : 10 grams taken twice a day
- once after breakfast and once after dinner.
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All Inclusive (Free Shipping)
(Total shipped weight
is 1.6 Pounds. Shipping cost is borne by us)
We will ship the herbal formulation
BREATHE EAZY to reach your home/office anywhere in the world within 10
days from the date of ordering.
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Bottles (200 grams/Bottle) -
30 Days course
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- 3
Bottles of the herbal formulation containing 14
Herbs in granule form. Each bottle contains 200 grams of
the herbal formulation in granule form.
Dosage : 10 grams taken twice a day
- once after breakfast and once after dinner.
U.S.$49/-
All Inclusive (Free Shipping)
(Total shipped weight
is 1.6 Pounds. Shipping cost is borne by us)
We will ship the herbal formulation
BREATHE EAZY to reach your home/office anywhere in the world within 10
days from the date of ordering.
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US FDA DSHEA
1994 Disclaimer :
This Herbal
product is not meant to diagnose ,treat or
cure any ailment and it does not
replace the need of a regular doctor
. The therapeutic properties of the
individual Herbs have not been evaluated
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